The 3D-printed implants were shown to speed up the healing of wounds and could be adapted to regenerate different tissues in the body.
A new study led by researchers at the RCSI University of Medicine and Health Sciences indicates that wound healing could be improved by replicating a key component of our blood.
Researchers focused on platelet-rich plasma (PRP), which is a natural healing substance in our blood. They extracted PRP from the blood of patients with complex skin wounds and manipulated the PRP through 3D printing to create a tissue-repair implant.
This implant could be administered to a difficult-to-treat skin wound in a single surgical procedure.
Results suggested that the implant could help to speed up wound healing by improving the development of new blood vessels and inhibiting the formation of scarring, which are both essential for a wound to heal effectively.
This indicates an improvement over the PRP already present in our blood, according to Prof Fergal O’Brien of RCSI, as natural PRP helps wounds to heal but scarring can still occur.
“By 3D-printing PRP into a biomaterial scaffold, we can increase the formation of blood vessels while also avoiding the formation of scars, leading to more successful wound healing.”
O’Brien, who is professor of bioengineering and regenerative medicine at RCSI, believes there are applications for this technology beyond skin wounds.
“This technology can potentially be used to regenerate different tissues, therefore dramatically influencing the ever-growing regenerative medicine, 3D printing and personalised medicine markets.”
The study was led by researchers at the Tissue Engineering Research Group and Science Foundation Ireland’s Advanced Materials and Bioengineering Research Centre (AMBER), based at RCSI’s Department of Anatomy and Regenerative Medicine.
The team also collaborated with researchers at the University of Minho in Portugal and at Trinity College Dublin’s Centre for Biomedical Engineering.
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